196 DANAZOL TREATMENT IN PUBERTAL GYNECOMASTIA

Prepubertal and Pubertal Gynecomastia

Physiology and molecular mechanisms Gynecomastia is defined as the growth of the male mammary gland to become palpable and/or visible. During embryogenesis, the differentiation of the mammary gland and surrounding estroma, as well as the areola and the nipple, is similar in the two sexes. It is well established that estrogens stimulate breast growth. The production of estrogens during pregnancy...

Plasma phthalate levels in pubertal gynecomastia.

OBJECTIVE Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In th...

Pubertal Gynecomastia Coincides with Peak Height Velocity

OBJECTIVE Pubertal gynecomastia (PG) occurs in up to 65% of adolescent boys. In this study, we investigated the relationship between the ages at which PG and peak height velocity occur in pubertal boys. METHODS This was a prospective study that was designed to detect PG within three months of its emergence. We examined one hundred and six boys who were followed for short stature and/or delaye...

11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia.

Gynecomastia — Symptoms and Treatment

Gynecomastia is the breast enlargement in males, due to increased glandular proliferation. This is very common condition and mostly physiological in neonates, pubertal boys and elderly persons. Some cases are pathologic and secondary to drugs, chronic liver and kidney disease or hyperthyroidism. Majority are asymptomatic and do not need treatment. If treatment is needed, it should be tailored a...